diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index 9d534689..153c2af6 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -6,6 +6,8 @@ Changelog
 
 * Do specifier matching correctly when the specifier contains an epoch number
   and has more components than the version (:issue:`683`)
+* Support the experimental ``--disable-gil`` builds in packaging.tags
+  (:issue:`727`)
 * BREAKING: Make optional ``metadata.Metadata`` attributes default to ``None`` (:issue:`733`)
 * Fix errors when trying to access the ``description_content_type``, ``keywords``,
   and ``requires_python`` attributes on ``metadata.Metadata`` when those values
diff --git a/src/packaging/tags.py b/src/packaging/tags.py
index 37f33b1e..dc0bbb6d 100644
--- a/src/packaging/tags.py
+++ b/src/packaging/tags.py
@@ -4,6 +4,7 @@
 
 import logging
 import platform
+import re
 import struct
 import subprocess
 import sys
@@ -124,20 +125,37 @@ def _normalize_string(string: str) -> str:
     return string.replace(".", "_").replace("-", "_").replace(" ", "_")
 
 
-def _abi3_applies(python_version: PythonVersion) -> bool:
+def _is_threaded_cpython(abis: List[str]) -> bool:
+    """
+    Determine if the ABI corresponds to a threaded (`--disable-gil`) build.
+
+    The threaded builds are indicated by a "t" in the abiflags.
+    """
+    if len(abis) == 0:
+        return False
+    # expect e.g., cp313
+    m = re.match(r"cp\d+(.*)", abis[0])
+    if not m:
+        return False
+    abiflags = m.group(1)
+    return "t" in abiflags
+
+
+def _abi3_applies(python_version: PythonVersion, threading: bool) -> bool:
     """
     Determine if the Python version supports abi3.
 
-    PEP 384 was first implemented in Python 3.2.
+    PEP 384 was first implemented in Python 3.2. The threaded (`--disable-gil`)
+    builds do not support abi3.
     """
-    return len(python_version) > 1 and tuple(python_version) >= (3, 2)
+    return len(python_version) > 1 and tuple(python_version) >= (3, 2) and not threading
 
 
 def _cpython_abis(py_version: PythonVersion, warn: bool = False) -> List[str]:
     py_version = tuple(py_version)  # To allow for version comparison.
     abis = []
     version = _version_nodot(py_version[:2])
-    debug = pymalloc = ucs4 = ""
+    threading = debug = pymalloc = ucs4 = ""
     with_debug = _get_config_var("Py_DEBUG", warn)
     has_refcount = hasattr(sys, "gettotalrefcount")
     # Windows doesn't set Py_DEBUG, so checking for support of debug-compiled
@@ -146,6 +164,8 @@ def _cpython_abis(py_version: PythonVersion, warn: bool = False) -> List[str]:
     has_ext = "_d.pyd" in EXTENSION_SUFFIXES
     if with_debug or (with_debug is None and (has_refcount or has_ext)):
         debug = "d"
+    if py_version >= (3, 13) and _get_config_var("Py_NOGIL", warn):
+        threading = "t"
     if py_version < (3, 8):
         with_pymalloc = _get_config_var("WITH_PYMALLOC", warn)
         if with_pymalloc or with_pymalloc is None:
@@ -159,13 +179,8 @@ def _cpython_abis(py_version: PythonVersion, warn: bool = False) -> List[str]:
     elif debug:
         # Debug builds can also load "normal" extension modules.
         # We can also assume no UCS-4 or pymalloc requirement.
-        abis.append(f"cp{version}")
-    abis.insert(
-        0,
-        "cp{version}{debug}{pymalloc}{ucs4}".format(
-            version=version, debug=debug, pymalloc=pymalloc, ucs4=ucs4
-        ),
-    )
+        abis.append(f"cp{version}{threading}")
+    abis.insert(0, f"cp{version}{threading}{debug}{pymalloc}{ucs4}")
     return abis
 
 
@@ -213,11 +228,14 @@ def cpython_tags(
     for abi in abis:
         for platform_ in platforms:
             yield Tag(interpreter, abi, platform_)
-    if _abi3_applies(python_version):
+
+    threading = _is_threaded_cpython(abis)
+    use_abi3 = _abi3_applies(python_version, threading)
+    if use_abi3:
         yield from (Tag(interpreter, "abi3", platform_) for platform_ in platforms)
     yield from (Tag(interpreter, "none", platform_) for platform_ in platforms)
 
-    if _abi3_applies(python_version):
+    if use_abi3:
         for minor_version in range(python_version[1] - 1, 1, -1):
             for platform_ in platforms:
                 interpreter = "cp{version}".format(
diff --git a/tests/test_tags.py b/tests/test_tags.py
index c9e921e1..e7f1c583 100644
--- a/tests/test_tags.py
+++ b/tests/test_tags.py
@@ -781,6 +781,14 @@ def test_all_args(self):
             tags.Tag("cp32", "abi3", "plat2"),
         ]
 
+        result = list(tags.cpython_tags((3, 13), ["cp313t"], ["plat1", "plat2"]))
+        assert result == [
+            tags.Tag("cp313", "cp313t", "plat1"),
+            tags.Tag("cp313", "cp313t", "plat2"),
+            tags.Tag("cp313", "none", "plat1"),
+            tags.Tag("cp313", "none", "plat2"),
+        ]
+
     def test_python_version_defaults(self):
         tag = next(tags.cpython_tags(abis=["abi3"], platforms=["any"]))
         interpreter = "cp" + tags._version_nodot(sys.version_info[:2])
@@ -894,6 +902,17 @@ def test__generic_abi_graal(self, monkeypatch):
         monkeypatch.setattr(sysconfig, "get_config_var", config.__getitem__)
         assert tags._generic_abi() == ["graalpy_38_native"]
 
+    def test__generic_abi_disable_gil(self, monkeypatch):
+        config = {
+            "Py_DEBUG": False,
+            "EXT_SUFFIX": ".cpython-313t-x86_64-linux-gnu.so",
+            "WITH_PYMALLOC": 0,
+            "Py_NOGIL": 1,
+        }
+        monkeypatch.setattr(sysconfig, "get_config_var", config.__getitem__)
+        assert tags._generic_abi() == ["cp313t"]
+        assert tags._generic_abi() == tags._cpython_abis((3, 13))
+
     def test__generic_abi_none(self, monkeypatch):
         config = {"EXT_SUFFIX": "..so"}
         monkeypatch.setattr(sysconfig, "get_config_var", config.__getitem__)
@@ -922,6 +941,7 @@ def test__generic_abi_old_windows(self, monkeypatch):
             "EXT_SUFFIX": ".pyd",
             "Py_DEBUG": 0,
             "WITH_PYMALLOC": 0,
+            "Py_NOGIL": 0,
         }
         monkeypatch.setattr(sysconfig, "get_config_var", config.__getitem__)
         assert tags._generic_abi() == tags._cpython_abis(sys.version_info[:2])