diff --git a/CHANGELOG.md b/CHANGELOG.md
index 843a193c551..a4633093c90 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -15,7 +15,7 @@ This project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.htm
 - Add `"go.opentelemetry.io/contrib/config"` package that includes configuration models generated via go-jsonschema. (#4376)
 - Add `NewSDK` function to `"go.opentelemetry.io/contrib/config"`. The initial implementation only returns noop providers. (#4414)
 - Add metrics support (No-op, OTLP and Prometheus) to `go.opentelemetry.io/contrib/exporters/autoexport`. (#4229, #4479)
-- otelhttp: set unit on the server latency histogram (#4500)
+- otelhttp: set units on all instruments (#4500)
 
 ### Changed
 
diff --git a/instrumentation/net/http/otelhttp/handler.go b/instrumentation/net/http/otelhttp/handler.go
index a174c005037..b193d8254e0 100644
--- a/instrumentation/net/http/otelhttp/handler.go
+++ b/instrumentation/net/http/otelhttp/handler.go
@@ -107,13 +107,16 @@ func (h *middleware) createMeasures() {
 	h.counters = make(map[string]metric.Int64Counter)
 	h.valueRecorders = make(map[string]metric.Float64Histogram)
 
-	requestBytesCounter, err := h.meter.Int64Counter(RequestContentLength)
+	requestBytesCounter, err := h.meter.Int64Counter(RequestContentLength, metric.WithUnit("By"),
+		metric.WithDescription("Measures the size of HTTP request content length (uncompressed)"))
 	handleErr(err)
 
-	responseBytesCounter, err := h.meter.Int64Counter(ResponseContentLength)
+	responseBytesCounter, err := h.meter.Int64Counter(ResponseContentLength, metric.WithUnit("By"),
+		metric.WithDescription("Measures the size of HTTP response content length (uncompressed)"))
 	handleErr(err)
 
-	serverLatencyMeasure, err := h.meter.Float64Histogram(ServerLatency, metric.WithUnit("ms"))
+	serverLatencyMeasure, err := h.meter.Float64Histogram(ServerLatency, metric.WithUnit("ms"),
+		metric.WithDescription("Measures the duration of HTTP request handling"))
 	handleErr(err)
 
 	h.counters[RequestContentLength] = requestBytesCounter
diff --git a/instrumentation/net/http/otelhttp/test/handler_test.go b/instrumentation/net/http/otelhttp/test/handler_test.go
index 30eec741160..105041dad56 100644
--- a/instrumentation/net/http/otelhttp/test/handler_test.go
+++ b/instrumentation/net/http/otelhttp/test/handler_test.go
@@ -50,7 +50,9 @@ func assertScopeMetrics(t *testing.T, sm metricdata.ScopeMetrics, attrs attribut
 	require.Len(t, sm.Metrics, 3)
 
 	want := metricdata.Metrics{
-		Name: "http.server.request_content_length",
+		Name:        "http.server.request_content_length",
+		Description: "Measures the size of HTTP request content length (uncompressed)",
+		Unit:        "By",
 		Data: metricdata.Sum[int64]{
 			DataPoints:  []metricdata.DataPoint[int64]{{Attributes: attrs, Value: 0}},
 			Temporality: metricdata.CumulativeTemporality,
@@ -60,7 +62,9 @@ func assertScopeMetrics(t *testing.T, sm metricdata.ScopeMetrics, attrs attribut
 	metricdatatest.AssertEqual(t, want, sm.Metrics[0], metricdatatest.IgnoreTimestamp())
 
 	want = metricdata.Metrics{
-		Name: "http.server.response_content_length",
+		Name:        "http.server.response_content_length",
+		Description: "Measures the size of HTTP response content length (uncompressed)",
+		Unit:        "By",
 		Data: metricdata.Sum[int64]{
 			DataPoints:  []metricdata.DataPoint[int64]{{Attributes: attrs, Value: 11}},
 			Temporality: metricdata.CumulativeTemporality,