diff --git a/sqlite3.go b/sqlite3.go
index d5d645c0..42b329cc 100644
--- a/sqlite3.go
+++ b/sqlite3.go
@@ -21,7 +21,6 @@ package sqlite3
 #cgo CFLAGS: -DSQLITE_DEFAULT_WAL_SYNCHRONOUS=1
 #cgo CFLAGS: -DSQLITE_ENABLE_UPDATE_DELETE_LIMIT
 #cgo CFLAGS: -Wno-deprecated-declarations
-#cgo linux,!android CFLAGS: -DHAVE_PREAD64=1 -DHAVE_PWRITE64=1
 #cgo openbsd CFLAGS: -I/usr/local/include
 #cgo openbsd LDFLAGS: -L/usr/local/lib
 #cgo amd64 CFLAGS: -maes -msse4.1
@@ -49,6 +48,18 @@ package sqlite3
 # define SQLITE_DETERMINISTIC 0
 #endif
 
+#if defined(HAVE_PREAD64) && defined(HAVE_PWRITE64)
+# undef USE_PREAD
+# undef USE_PWRITE
+# define USE_PREAD64 1
+# define USE_PWRITE64 1
+#elif defined(HAVE_PREAD) && defined(HAVE_PWRITE)
+# undef USE_PREAD
+# undef USE_PWRITE
+# define USE_PREAD64 1
+# define USE_PWRITE64 1
+#endif
+
 static int
 _sqlite3_open_v2(const char *filename, sqlite3 **ppDb, int flags, const char *zVfs) {
 #ifdef SQLITE_OPEN_URI